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We study how different genes contribute to intellectual disability in neurodevelopmental disorders with a focus on Down syndrome.
We conduct large-scale analyses of zebrafish embryos to determine how genes and molecules influence neurodevelopment and function.
There are no effective treatments for most genetic neurodevelopmental disorders.
We are a friendly and sociable group of motivated researchers.
A single-cell transcriptome atlas of the maturing zebrafish telencephalon
Pandey S, Moyer AJ, Thyme SB.
Genome Res. 2023 Apr;33(4):658-671. doi: 10.1101/gr.277278.122. Epub 2023 Apr 18. PMID: 37072188; PMCID: PMC10234298.
We define the cell types in the zebrafish forebrain across multiple ages and discover how they change between larval and adult stages.
Diencephalic and Neuropeptidergic Dysfunction in Zebrafish with Autism Risk Mutations
, , , , , , , , , 2024. bioRxiv.
We generated 27 zebrafish mutants with presumptive protein-truncating mutations or specific missense variants corresponding to autism-risk alleles in 17 human genes.
A customizable low-cost system for massively parallel zebrafish behavioral phenotyping
William Joo, Michael D Vivian, Brett J Graham, Edward R Soucy, Summer B Thyme
2021. Frontiers in Behavioral Neuroscience
We provide a detailed construction manual for our home-built zebrafish behavior apparatus, as well as best practices for larval zebrafish behavioral experiments.
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